GlycoNAVI: CheGly (Chemical Glycosylation)
ACT

Prumycin

ID Compound Name Target Name Species Assay Method Activity Value Conditions DOI
act3454PrumycinStaphylococcus aureus FDA 209PMIC (mcg/ml)>100Medium: N10.7164/antibiotics.24.900
act3455PrumycinBacillus subtilis PCI 219MIC (mcg/ml)>100Medium: N10.7164/antibiotics.24.900
act3456PrumycinSarcina lutea PCI 1001MIC (mcg/ml)3.12Medium: N10.7164/antibiotics.24.900
act3457PrumycinSalmonella typhimuriumMIC (mcg/ml)>100Medium: N10.7164/antibiotics.24.900
act3458PrumycinEscherichia coli NIHJMIC (mcg/ml)100Medium: N10.7164/antibiotics.24.900
act3459PrumycinPseudomonas aeruginosa P-3MIC (mcg/ml)>100Medium: N10.7164/antibiotics.24.900
act3460PrumycinKlebsiella pneumoniaeMIC (mcg/ml)>100Medium: N10.7164/antibiotics.24.900
act3461PrumycinShigella sonneiMIC (mcg/ml)100Medium: N10.7164/antibiotics.24.900
act3462PrumycinVibrio comma904MIC (mcg/ml)12.5Medium: N10.7164/antibiotics.24.900
act3463PrumycinProteus vulgaris OX-19MIC (mcg/ml)>100Medium: N10.7164/antibiotics.24.900
act3464PrumycinMycobacterium ATCC 607MIC (mcg/ml)>100Medium: N10.7164/antibiotics.24.900
act3465PrumycinXanthomonas oryzaeMIC (mcg/ml)50Medium: N10.7164/antibiotics.24.900
act3466PrumycinXanthomonas citriMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3467PrumycinAlternaria maliMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3468PrumycinAlternaria kikuchianaMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3469PrumycinAlternaria japonicaMIC (mcg/ml)50Medium: P10.7164/antibiotics.24.900
act3470PrumycinSclerotinia cinereaMIC (mcg/ml)12.5Medium: P10.7164/antibiotics.24.900
act3471PrumycinSclerotinia sclerotiorumMIC (mcg/ml)1.56Medium: P10.7164/antibiotics.24.900
act3472PrumycinBotorytis fabaeMIC (mcg/ml)6.25Medium: P10.7164/antibiotics.24.900
act3473PrumycinBotorytis cinereaMIC (mcg/ml)6.25Medium: P10.7164/antibiotics.24.900
act3474PrumycinBotorytis cryptoneriaeMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3475PrumycinCochliobolus miyabeanusMIC (mcg/ml)50Medium: P10.7164/antibiotics.24.900
act3476PrumycinCoilectotrichum lagenariumMIC (mcg/ml)50Medium: P10.7164/antibiotics.24.900
act3477PrumycinCandida albicansMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3478PrumycinSaccharomyces cerevisiaeMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3479PrumycinCryptococcus neoformansMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3480PrumycinHormodendrum pedrosoiMIC (mcg/ml)25Medium: P10.7164/antibiotics.24.900
act3481PrumycinFusarium moniliforme XJSDA1004-1MIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3482PrumycinPenicillium notatumMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3483PrumycinTrichophyton rubrumMIC (mcg/ml)100Medium: P10.7164/antibiotics.24.900
act3484PrumycinTrichophyton mentagrophytesMIC (mcg/ml)100Medium: P10.7164/antibiotics.24.900
act3485PrumycinTrichosporon beigelliiMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3486PrumycinGlasosporium laeticolotorMIC (mcg/ml)50Medium: P10.7164/antibiotics.24.900
act3487PrumycinGlomerella cingulataMIC (mcg/ml)100Medium: P10.7164/antibiotics.24.900
act3488PrumycinOphiobolus miyabeanusMIC (mcg/ml)25Medium: P10.7164/antibiotics.24.900
act3489PrumycinAspergillus nigerMIC (mcg/ml)>100Medium: P10.7164/antibiotics.24.900
act3490PrumycinFusarium oxysporumMIC (µg/ml)>100Medium: P10.7164/antibiotics.24.900
act3491PrumycinPiricularia oryzaeMIC (µg/ml)>100Medium: P10.7164/antibiotics.24.900
act3492PrumycinCephalosporium caerulensMIC (µg/ml)>100Medium: P10.7164/antibiotics.24.900
act3493PrumycinTrichophyton rubrumMIC (µg/ml)>100Medium: P10.7164/antibiotics.24.900
act3494PrumycinSc. sclerotiorumDiseased zone (mm)\nInhibition (%)23.0 23Concentration (ppm) 12.510.7164/antibiotics.24.900
act3495PrumycinSc. sclerotiorumDiseased zone (mm)\nInhibition (%)23.0 23Concentration (ppm) 25.010.7164/antibiotics.24.900
act3496PrumycinSc. sclerotiorumDiseased zone (mm)\nInhibition (%)10.0 67Concentration (ppm) 50.010.7164/antibiotics.24.900
act3497PrumycinSc. sclerotiorumDiseased zone (mm)\nInhibition (%)10.0 67Concentration (ppm) 100.010.7164/antibiotics.24.900
act3498PrumycinSc. sclerotiorumDiseased zone (mm)\nInhibition (%)30.0 0Concentration (ppm) None10.7164/antibiotics.24.900
act3499PrumycinBot. cinereaDiseased zone (mm)\nInhibition (%)13.0 63Concentration (ppm) 12.510.7164/antibiotics.24.900
act3500PrumycinBot. cinereaDiseased zone (mm)\nInhibition (%)10.0 71Concentration (ppm) 25.010.7164/antibiotics.24.900
act3501PrumycinBot. cinereaDiseased zone (mm)\nInhibition (%)0 100Concentration (ppm) 50.010.7164/antibiotics.24.900
act3502PrumycinBot. cinereaDiseased zone (mm)\nInhibition (%)0 100Concentration (ppm) 100.010.7164/antibiotics.24.900
act3503PrumycinBot. cinereaDiseased zone (mm)\nInhibition (%)35.0 0Concentration (ppm) None10.7164/antibiotics.24.900
act3504PrumycinSc. sclerotiorumDiseased zone after treatment (mm)\nInhibition (%)23.6 48Concentration (ppm) 12.510.7164/antibiotics.24.900
act3505PrumycinSc. sclerotiorumDiseased zone after treatment (mm)\nInhibition (%)20.1 60Concentration (ppm) 25.010.7164/antibiotics.24.900
act3506PrumycinSc. sclerotiorumDiseased zone after treatment (mm)\nInhibition (%)19.3 63Concentration (ppm) 50.010.7164/antibiotics.24.900
act3507PrumycinSc. sclerotiorumDiseased zone after treatment (mm)\nInhibition (%)16.3 86Concentration (ppm) 100.010.7164/antibiotics.24.900
act3508PrumycinSc. sclerotiorumDiseased zone after treatment (mm)\nInhibition (%)33.0 0Concentration (ppm) None10.7164/antibiotics.24.900
act3509PrumycinBot. cinereaDiseased zone after treatment (mm)\nInhibition (%)20.3 49Concentration (ppm) 12.510.7164/antibiotics.24.900
act3510PrumycinBot. cinereaDiseased zone after treatment (mm)\nInhibition (%)19.3 57Concentration (ppm) 25.010.7164/antibiotics.24.900
act3511PrumycinBot. cinereaDiseased zone after treatment (mm)\nInhibition (%)17.0 76Concentration (ppm) 50.010.7164/antibiotics.24.900
act3512PrumycinBot. cinereaDiseased zone after treatment (mm)\nInhibition (%)16.3 81Concentration (ppm) 100.010.7164/antibiotics.24.900
act3513PrumycinBot. cinereaDiseased zone after treatment (mm)\nInhibition (%)26.3 0Concentration (ppm) None10.7164/antibiotics.24.900
act3514Prumycinsarcoma 180 (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C (Day 7)\nBody wt. change (g)\nWBC (/mm^3)150 313±126 0.42 +0.9 8800Treatment schedule Day 1 White blood cell counts on days 410.7164/antibiotics.24.900
act3515Prumycinsarcoma 180 (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C (Day 7)\nBody wt. change (g)\nWBC (/mm^3)100 353±110 0.47 +0.5 8800Treatment schedule Day 1 White blood cell counts on days 410.7164/antibiotics.24.900
act3516Prumycinsarcoma 180 (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C (Day 7)\nBody wt. change (g)\nWBC (/mm^3)75 366±99 0.49 +1.3 8800Treatment schedule Day 1 White blood cell counts on days 410.7164/antibiotics.24.900
act3517Prumycinsarcoma 180 (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C (Day 7)\nBody wt. change (g)\nWBC (/mm^3)50 661±265 0.88 +3.6 N.T.Treatment schedule Day 110.7164/antibiotics.24.900
act3518Prumycinsarcoma 180 (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C (Day 7)\nBody wt. change (g)\nWBC (/mm^3)20 286±94 0.38 -3.6 11100Treatment schedule Day 1 ~ 6 White blood cell counts on days 710.7164/antibiotics.24.900
act3519Prumycinsarcoma 180 (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C (Day 7)\nBody wt. change (g)\nWBC (/mm^3)10 457±134 0.61 +0.4 N.T.Treatment schedule Day 1 ~ 610.7164/antibiotics.24.900
act3520Prumycinsarcoma 180 (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C (Day 7)\nBody wt. change (g)\nWBC (/mm^3)5 621±164 0.83 +2.3 N.T.Treatment schedule Day 1 ~ 610.7164/antibiotics.24.900
act3521PrumycinP-388 (i.p.-i.p.)Dose (mg/kg/day)\nSurvival days (Mean±SD)\nILS (%)200 13.4±4.5 31Treatment schedule Day 110.7164/antibiotics.24.900
act3522PrumycinP-388 (i.p.-i.p.)Dose (mg/kg/day)\nSurvival days (Mean±SD)\nILS (%)150 15.2±0.4 50Treatment schedule Day 110.7164/antibiotics.24.900
act3523PrumycinP-388 (i.p.-i.p.)Dose (mg/kg/day)\nSurvival days (Mean±SD)\nILS (%)100 13.8±1.0 40Treatment schedule Day 110.7164/antibiotics.24.900
act3524PrumycinP-388 (i.p.-i.p.)Dose (mg/kg/day)\nSurvival days (Mean±SD)\nILS (%)75 13.2±1.0 30Treatment schedule Day 110.7164/antibiotics.24.900
act3525PrumycinP-388 (i.p.-i.p.)Dose (mg/kg/day)\nSurvival days (Mean±SD)\nILS (%)20 15.0±5.9 38Treatment schedule Day 1 ~ 710.7164/antibiotics.24.900
act3526PrumycinP-388 (i.p.-i.p.)Dose (mg/kg/day)\nSurvival days (Mean±SD)\nILS (%)10 14.2±3.2 31Treatment schedule Day 1 ~ 710.7164/antibiotics.24.900
act3527PrumycinP-388 (i.p.-i.p.)Dose (mg/kg/day)\nSurvival days (Mean±SD)\nILS (%)5 14.0±2.1 30Treatment schedule Day 1 ~ 710.7164/antibiotics.24.900
act3528Prumycinmethylcholanthrene-induced sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)150 37.6±25.8 0.29 +0.3on Day 710.7164/antibiotics.24.900
act3529Prumycinmethylcholanthrene-induced sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)100 46.4±23.5 0.35 +0.8on Day 710.7164/antibiotics.24.900
act3530Prumycinmethylcholanthrene-induced sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)75 56.0±14.7 0.29 +0.3on Day 710.7164/antibiotics.24.900
act3531Prumycinmethylcholanthrene-induced sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)150 464±216 0.57 +1.3on Day 1410.7164/antibiotics.24.900
act3532Prumycinmethylcholanthrene-induced sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)100 573±145 0.71 +1.2on Day 1410.7164/antibiotics.24.900
act3533Prumycinmethylcholanthrene-induced sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)75 682±166 0.84 +0.8on Day 1410.7164/antibiotics.24.900
act3534PrumycinLEWIS lung carcinomaDose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)75 729±355 0.33 -3.5on Day 1610.7164/antibiotics.24.900
act3535PrumycinLEWIS lung carcinomaDose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)50 1313±249 0.60 -0.5on Day 1610.7164/antibiotics.24.900
act3536PrumycinLEWIS lung carcinomaDose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)25 1793±235 0.82 +0.9on Day 1610.7164/antibiotics.24.900
act3537PrumycinLEWIS lung carcinomaDose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)75 2241±1903 0.53 +0.8on Day 2010.7164/antibiotics.24.900
act3538PrumycinLEWIS lung carcinomaDose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)50 2770±1053 0.65 +4.3on Day 2010.7164/antibiotics.24.900
act3539PrumycinLEWIS lung carcinomaDose (mg/kg/day)\nTumor volume (mm^3) (Mean±SD)\nT/C \nBody wt. change (g)25 3269±490 0.77 +5.3on Day 2010.7164/antibiotics.24.900
act3540PrumycinYOSHIDA sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor weight (g) (Mean±SD)\nT/C (day 8)\nBody wt. change (g)33.8 2.55±0.96 0.88 -3.8Treatment schedule Days 1, 4, 710.7164/antibiotics.24.900
act3541PrumycinYOSHIDA sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor weight (g) (Mean±SD)\nT/C (day 8)\nBody wt. change (g)22.5 2.09±0.73 0.72 +17.2Treatment schedule Days 1, 4, 710.7164/antibiotics.24.900
act3542PrumycinYOSHIDA sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor weight (g) (Mean±SD)\nT/C (day 8)\nBody wt. change (g)16.9 3.17±0.76 1.10 +11.0Treatment schedule Days 1, 4, 710.7164/antibiotics.24.900
act3543PrumycinYOSHIDA sarcoma (s.c.-i.p.)Dose (mg/kg/day)\nTumor weight (g) (Mean±SD)\nT/C (day 8)\nBody wt. change (g)50 2.76±1.14 0.96 +10.9Treatment schedule Day 110.7164/antibiotics.24.900
act3544PrumycinYOSHIDA sarcoma (s.c.-i.p.)LD50 (mg/kg)67.510.7164/antibiotics.24.900
act3545PrumycinAH-130 (s.c.-i.p.)Dose (mg/kg/day)\nTumor weight (g) (Mean±SD)\nT/C (day 10)\nBody wt. change (g)22.5 2.19±0.82 0.45 +13.1Treatment schedule Days 1, 4, 710.7164/antibiotics.24.900
act3546PrumycinAH-130 (s.c.-i.p.)Dose (mg/kg/day)\nTumor weight (g) (Mean±SD)\nT/C (day 10)\nBody wt. change (g)16.9 2. 50±1 .68 0.51 +22.3Treatment schedule Days 1, 4, 710.7164/antibiotics.24.900
act3547PrumycinAH-130 (s.c.-i.p.)Dose (mg/kg/day)\nTumor weight (g) (Mean±SD)\nT/C (day 10)\nBody wt. change (g)13.5 2.13±1.65 0.58 +23.8Treatment schedule Days 1, 4, 710.7164/antibiotics.24.900
act3548PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration (Day 0)100 Mortality 1/110.7164/antibiotics.24.900
act3549PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration (Day 0)100 Symptoms Vomiting10.7164/antibiotics.24.900
act3550PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration (Day 0)50 Mortality 1/210.7164/antibiotics.24.900
act3551PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 350 Mortality 1/210.7164/antibiotics.24.900
act3552PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 550 Mortality 1/210.7164/antibiotics.24.900
act3553PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 1450 Mortality 1/210.7164/antibiotics.24.900
act3554PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration (Day 0)50 Symptoms Vomiting10.7164/antibiotics.24.900
act3555PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration (Day 0)30 Mortality 0/110.7164/antibiotics.24.900
act3556PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 330 Mortality 0/110.7164/antibiotics.24.900
act3557PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 530 Mortality 0/110.7164/antibiotics.24.900
act3558PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 1430 Mortality 0/110.7164/antibiotics.24.900
act3559PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration (Day 0)30 Symptoms Vomiting10.7164/antibiotics.24.900
act3560PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 1430 Symptoms (no alopecia)10.7164/antibiotics.24.900
act3561PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Time 030 Body wt. (kg) 1110.7164/antibiotics.24.900
act3562PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 330 Body wt. (kg) 1010.7164/antibiotics.24.900
act3563PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 530 Body wt. (kg) 1110.7164/antibiotics.24.900
act3564PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 1430 Body wt. (kg) 1110.7164/antibiotics.24.900
act3565PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Time 030 WBC (/mm3) 1170010.7164/antibiotics.24.900
act3566PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 330 WBC (/mm3) 1090010.7164/antibiotics.24.900
act3567PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 530 WBC (/mm3) 1170010.7164/antibiotics.24.900
act3568PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 1430 WBC (/mm3) 1150010.7164/antibiotics.24.900
act3569PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Time 030 BUN (mg/dl) 14.610.7164/antibiotics.24.900
act3570PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 330 BUN (mg/dl) 16.310.7164/antibiotics.24.900
act3571PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 530 BUN (mg/dl) 14.010.7164/antibiotics.24.900
act3572PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 1430 BUN (mg/dl) 15.010.7164/antibiotics.24.900
act3573PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration (Day 0)20 Mortality 0/210.7164/antibiotics.24.900
act3574PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 320 Mortality 0/210.7164/antibiotics.24.900
act3575PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 520 Mortality 0/210.7164/antibiotics.24.900
act3576PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration Day 1420 Mortality 0/210.7164/antibiotics.24.900
act3577PrumycinToxicity and side effects of prumycin in dogDose (mg/kg)\nItems of examination\nTime after the administration (Day 0)20 Symptoms Vomiting10.7164/antibiotics.24.900
act3578PrumycinHeLaIC50 (mcg/ml)310.7164/antibiotics.24.900
act3579PrumycinEffect of prumycin on antibody-forming cells in mouse spleenon Day 4\nPFC/10^6 spleen cells (%)\nPFC/spleen (×10^3) (%)1552±202 (87) 543±71 (91)Prumycin 75 mg/kg i.p. Time of administration Day 010.7164/antibiotics.24.900
act3580PrumycinEffect of prumycin on antibody-forming cells in mouse spleenon Day 4\nPFC/10^6 spleen cells (%)\nPFC/spleen (×10^3) (%)1818±251 (102) 601±13 (101)Prumycin 75 mg/kg i.p. Time of administration Day 110.7164/antibiotics.24.900
act3581PrumycinEffect of prumycin on antibody-forming cells in mouse spleenon Day 4\nPFC/10^6 spleen cells (%)\nPFC/spleen (×10^3) (%)1751±171 (99) 595±26 (100)Prumycin 75 mg/kg i.p. Time of administration Day 210.7164/antibiotics.24.900
act3582PrumycinEffect of prumycin on antibody-forming cells in mouse spleenon Day 4\nPFC/10^6 spleen cells (%)\nPFC/spleen (×10^3) (%)1155±301 (65) 386±84 (65)Prumycin 75 mg/kg i.p. Time of administration Day 310.7164/antibiotics.24.900
act3583PrumycinEffect of prumycin on antibody production of hemolytic plaque forming cells in vitro.PFC/10^6 spleen cells \n(%)125±31 12Concentration (mcg/ml) 100010.7164/antibiotics.24.900
act3584PrumycinEffect of prumycin on antibody production of hemolytic plaque forming cells in vitro.PFC/10^6 spleen cells \n(%)156±26 15Concentration (mcg/ml) 25010.7164/antibiotics.24.900
act3585PrumycinEffect of prumycin on antibody production of hemolytic plaque forming cells in vitro.PFC/10^6 spleen cells \n(%)406±29 38Concentration (mcg/ml) 62.510.7164/antibiotics.24.900
act3586PrumycinEffect of prumycin on antibody production of hemolytic plaque forming cells in vitro.PFC/10^6 spleen cells \n(%)594±30 56Concentration (mcg/ml) 15.710.7164/antibiotics.24.900
act3587PrumycinEffect of prumycin on antibody production of hemolytic plaque forming cells in vitro.PFC/10^6 spleen cells \n(%)813±108 77Concentration (mcg/ml) 3.910.7164/antibiotics.24.900
act3588PrumycinEffect of prumycin on mouse delayed-type hypersensitivity reaction.Dose (mg/kg)\nTime (Day)\nFoot pad swelling (1/100 mm)\n%10 -2~+3 102±2 10610.7164/antibiotics.24.900
act3589PrumycinEffect of prumycin on mouse delayed-type hypersensitivity reaction.Dose (mg/kg)\nTime (Day)\nFoot pad swelling (1/100 mm)\n%75 -1 76±8 7910.7164/antibiotics.24.900
act3590PrumycinEffect of prumycin on mouse delayed-type hypersensitivity reaction.Dose (mg/kg)\nTime (Day)\nFoot pad swelling (1/100 mm)\n%75 0 96±10 10010.7164/antibiotics.24.900
act3591PrumycinEffect of prumycin on mouse delayed-type hypersensitivity reaction.Dose (mg/kg)\nTime (Day)\nFoot pad swelling (1/100 mm)\n%75 +1 80±22 8310.7164/antibiotics.24.900
act3592PrumycinEffect of prumycin on mouse delayed-type hypersensitivity reaction.Dose (mg/kg)\nTime (Day)\nFoot pad swelling (1/100 mm)\n%75 +3 61±8 6410.7164/antibiotics.24.900
act3593PrumycinEffect of prumycin on mouse delayed-type hypersensitivity reaction.Dose (mg/kg)\nTime (Day)\nFoot pad swelling (1/100 mm)\n%75 +4 48±12 5010.7164/antibiotics.24.900
act3594PrumycinEffect of prumycin on mouse lymphocytes blastogenic stimulation in vitro.Blastgenic stimulation\n-PHA (cpm)\n%\n+PHA (cpm)\n%353±30 12 252±111 1Concentration (mcg/ml) 3010.7164/antibiotics.24.900
act3595PrumycinEffect of prumycin on mouse lymphocytes blastogenic stimulation in vitro.Blastgenic stimulation\n-PHA (cpm)\n%\n+PHA (cpm)\n%2050±164 67 12932±548 49Concentration (mcg/ml) 7.510.7164/antibiotics.24.900
act3596PrumycinEffect of prumycin on mouse lymphocytes blastogenic stimulation in vitro.Blastgenic stimulation\n-PHA (cpm)\n%\n+PHA (cpm)\n%5130±417 169 34199±1362 140Concentration (mcg/ml) 1.910.7164/antibiotics.24.900
act3597PrumycinEffect of prumycin on mouse lymphocytes blastogenic stimulation in vitro.Blastgenic stimulation\n-PHA (cpm)\n%\n+PHA (cpm)\n%5033±967 168 31578±1013 129Concentration (mcg/ml) 0.4710.7164/antibiotics.24.900
act3598PrumycinEffect of prumycin on mouse lymphocytes blastogenic stimulation in vitro.Blastgenic stimulation\n-PHA (cpm)\n%\n+PHA (cpm)\n%4798±636 158 27525±1484 112Concentration (mcg/ml) 0.1210.7164/antibiotics.24.900
act3599PrumycinEffect of prumycin on mouse lymphocytes blastogenic stimulation in vitro.Blastgenic stimulation\n-PHA (cpm)\n%\n+PHA (cpm)\n%3979±872 131 26579±1116 109Concentration (mcg/ml) 0.0310.7164/antibiotics.24.900
act3600PrumycinK1 strain (drug-resistant strain)IC50 (µg/ml)0.1610.7164/antibiotics.24.900
act3601PrumycinFCR3 strain (drug-sensitive strain)IC50 (µg/ml)0.1710.7164/antibiotics.24.900
act3602PrumycinP. berghei N (drug-sensitive strain)ED50 (mg/kg)\nED90 (mg/kg)6.2 17.010.7164/antibiotics.24.900
act3603PrumycinP. yoelii ssp. NS (chloroquine-resistant strain)ED50 (mg/kg)\nED90 (mg/kg)10.2 27.810.7164/antibiotics.24.900